A driver is facing charges after police in Port St. Lucie said he was involved in a road-rage pursuit and crash that left a motorcyclist and three others hospitalized.

The incident happened Wednesday evening when the driver of a Ford Super Duty pickup and the driver of a Harley-Davidson were involved in an ongoing road-rage incident on U.S. 1, Port St. Lucie Police officials said.

The pickup was pursuing the Harley as they approached the intersection at Southeast Lyngate Drive/Southeast Tiffany Avenue, where the motorcycle went through a red light and crashed into a Chevrolet Silverado, ejecting the motorcycle rider, police said.

Police said the pickup also ran the red light and hit the motorcycle rider before crashing head-on into a Toyota RAV4.

The 31-year-old motorcycle rider was hospitalized with serious injuries, including a brain bleed and facial fractures.

Two people in the RAV4 and the driver of the Silverado were also hospitalized.

The driver of the Ford pickup, 54-year-old Kevin Patrick Lonergan, was hospitalized and later arrested on charges including reckless driving causing damage to person or property and reckless driving causing serious bodily injury.